Lemon Bottle 10ML

At a glance

Strength

10 ml

PubChem CID

493570 (riboflavin); 16213884 (lecithin)

What Lemon Bottle is

The manufacturer's official store names SID Medicos as the vendor and describes the product as "a non-surgical body-contouring solution that targets stubborn fat" ¹. The same page says it is "formulated with natural ingredients" ¹. These are marketing statements, not findings from a published study.

FDA traced the brand through a package it bought on Amazon: a QR code sticker led to a page linking to lemonbottle.net, which then redirected to sidmedicos.com ². FDA quoted that website's claims, including "LEMONBOTTLE LIPOLYSIS", that riboflavin "helps discharge dissolved fat from our body faster than normal metabolism speed" and that lecithin "breaks down first cell fat membrane" ². FDA treated these claims as evidence that the product is intended to affect the structure or function of the body, which makes it a drug under US law ².

Declared ingredients

The manufacturer lists the full ingredients as water (aqua), Ananas sativus (pineapple) fruit extract, pentylene glycol, bromelain, sodium chloride, lecithin, Centella asiatica extract, Salvia miltiorrhiza root extract, Chamomilla recutita (matricaria) extract, Scutellaria baicalensis root extract and riboflavin ¹. It states that bromelain "helps dissolve fat", that lecithin "breaks down and transports unwanted fat cells" and that riboflavin "activates your body's natural fat metabolism" ¹.

The list contains no deoxycholic acid or other bile salt ¹, the ingredient that research on older fat-dissolving formulations identified as the main agent of cell lysis ⁵. It also contains no vitamin B12 ¹, so Lemon Bottle is a different formulation from Lipo-C + B12.

What is known about each ingredient

Bromelain

Bromelain is a concentrated mixture of proteins and enzymes made from the stems and fruit of the pineapple plant, Ananas comosus ⁶. A 2001 review describes it as a crude extract containing several closely related proteinases, whose active factors are only partly characterised ⁷. LiverTox describes its use on the skin for wounds and burns and by mouth for digestive complaints, and notes that it is generally recognized as safe (GRAS) and has not been linked to liver injury ⁶. In a 2012 cell-culture study in mouse 3T3-L1 adipocytes, stem bromelain inhibited adipocyte differentiation and induced apoptosis and lipolysis in mature cells, through a pathway involving TNF-alpha ⁸. That study used a cell line only; it did not test bromelain in animals, people or any branded product ⁸.

Riboflavin

Riboflavin is vitamin B2, PubChem CID 493570, with the formula C17H20N4O6 and a molecular weight of 376.4 g/mol ⁹. In tissues it occurs mainly as flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) ⁹. In those cofactor forms it has fundamental roles in energy metabolism and cellular antioxidant capacity ¹⁰. As of October 2026 this page found no study showing that riboflavin placed in fat changes the amount of fat there.

Lecithin and phosphatidylcholine

Lecithin is a mixture of choline, choline esters, fatty acids, glycerol, glycolipids, triglycerides, phosphoric acid and phospholipids such as phosphatidylcholine ¹¹. PubChem files "lecithin" under CID 16213884, a single phosphatidylcholine, PC(16:0/18:2), with the formula C42H80NO8P ¹². The fat-dissolving formulations studied in the 2000s combined phosphatidylcholine with sodium deoxycholate, a bile salt used to make the phospholipid soluble in water ⁵. In cell cultures and pig skin, that formulation and deoxycholate alone caused comparable membrane lysis, like laboratory detergents, and the authors concluded that deoxycholate was the major active component ⁵. A randomized double-blind trial in 42 people then compared deoxycholate alone with the phosphatidylcholine-deoxycholate mixture in fat under the chin ¹³. It found minimal aesthetic improvement overall and no apparent difference in efficacy or adverse events from adding phosphatidylcholine ¹³. These studies do not show what lecithin does in tissue without a bile salt, which is how Lemon Bottle's list describes it ¹.

How it differs from Kybella (deoxycholic acid)

FDA approved Kybella under New Drug Application 206333 on April 29, 2015, as a new molecular entity ¹⁴. Its label lists one active ingredient, deoxycholic acid at 10 mg/mL, a cytolytic agent that physically destroys cell membranes, indicated only for moderate to severe fullness associated with fat under the chin in adults ¹⁵. The label states that it is not approved for fat outside that region and warns of serious adverse reactions after such unapproved use ¹⁵.

The approval rests on placebo-controlled phase 3 trials. In REFINE-1, 256 people received the drug and 250 received placebo; a composite improvement of at least one grade was seen in 70.0% and 18.6%, and the share of MRI responders was 46.3% and 5.3% ¹⁶. REFINE-2, with 258 people per group, reported a composite improvement of at least one grade in 66.5% and 22.2% ¹⁷. By contrast, Lemon Bottle's declared list contains no deoxycholic acid ¹, and FDA states there is no approved application for it ².

Regulatory status

United States (as of October 2026). On March 3, 2025, FDA sent warning letters to Amazon.com and to Fox Pharma LLC, a US seller, naming "LemonBottle Ampoule Solution" with other lipolytic products ²³. FDA found these products were not generally recognized as safe and effective for the claimed uses, so they are new drugs that may not be shipped between states without an approved application ². The Fox Pharma letter quoted seller claims that lecithin "destroys and transports unnecessary fat cells" and that bromelain "helps to break down fat" ³. Drugs that FDA approves go through a new drug application; Wegovy (semaglutide), for example, is approved under NDA 215256 ¹⁸. Lemon Bottle has no such application ².

United Kingdom (as of October 2026). UK government guidance defines cosmetics as products for the external parts of the body, such as the skin surface, hair, nails and lips ¹⁹. The same guidance states that products intended to be swallowed, inhaled, implanted or put into the body by needle are not classified as cosmetic products ¹⁹. In 2023 the government consulted on licensing non-surgical cosmetic procedures in England and proposed placing lipolysis with a prescription-only medicine in a middle ("amber") tier ²⁰. Its summary of responses cites Lemon Bottle as an example of a cosmetic product used for lipolysis, which some respondents said should be added to that tier ²⁰. The government's August 2025 response said further work was needed to decide where specific procedures will sit, and the regulations had not yet come into force ²⁰.

Reported safety concerns

FDA's warning letters say that products placed into the body bypass some of its key defences against toxins and microorganisms, which can lead to serious and life-threatening conditions ². FDA's 2023 consumer page lists permanent scars, serious infections, skin deformities, cysts and deep, painful knots reported after unapproved fat-dissolving products in general ⁴. The brands it names are Aqualyx, Lipodissolve, Lipo Lab and Kabelline, "and others"; it does not name Lemon Bottle ⁴. A 2026 case report described acute respiratory distress syndrome in a woman after a session of fat-dissolving treatments and breast filler at an unlicensed facility; it names the products used as Vline Body (described as water and lecithin), Lignospan and Botox, not Lemon Bottle ²¹.

What is not known

No peer-reviewed trial, case series or case report naming Lemon Bottle was found in PubMed or PubMed Central on October 17, 2026. Because the manufacturer does not publish concentrations ¹, the amount of each ingredient in a vial cannot be checked against its label from public sources. As of October 2026 this page also found no controlled study of riboflavin, bromelain or lecithin without a bile salt placed in human fat tissue. Published certificates of analysis are listed with our lab results.